A Comparison of the Capacity of Mesenchymal Stromal Cells for Cartilage Regeneration Depending on Collagen-Based Injectable Biomimetic Scaffold Type

Mesenchymal stromal cells (MSCs) have shown a high potential for cartilage repair. Collagen-based scaffolds are used to deliver and retain at the site of damage. The aim work was comparative analysis capacity MSCs from human adipose tissue differentiate into chondrocytes in vitro stimulate regeneration articular an experimental model rabbit knee osteoarthrosis when cultured on microheterogenic collagen-based hydrogel (MCH) microparticles decellularized porcine (DPC). morphology samples evaluated using scanning electron microscopy histological staining methods. On surface DPC, were distributed more uniformly than MCH surface. day 28, DPC produced glycosaminoglycans intensely compared with synthesis collagen type II. However, osteoarthrosis, stimulation effective administered carrier. present study demonstrates way regulate action area regeneration: is conducive stimulating repair by MSCs, while inducer formation cartilage-like vitro.